Dermatol Clin. Jul;11(3) Epidermolysis bullosa acquisita and bullous systemic lupus erythematosus. Diseases of autoimmunity to type VII collagen. Bullous Systemic Lupus Erythematosus (BSLE) is a rare manifestation of . (BP), inflammatory variant of epidermolysis bullosa acquisita (EBA), and linear IgA. However, unlike epidermolysis bullosa acquisita, bullous systemic lupus erythematosus tends to respond dramatically to treatment with.
|Published (Last):||8 August 2009|
|PDF File Size:||18.10 Mb|
|ePub File Size:||5.31 Mb|
|Price:||Free* [*Free Regsitration Required]|
Author information Article notes Copyright and License information Disclaimer. Int J Dermatol, 36pp. We described a patient who developed severe bullous lesions 14 days after high-dose systemic glucocorticoids and cyclophosphide therapies were initiated for severe SLE manifestations nephritis and alveolar hemorrhage. Management of Blistering Diseases. J Am Acad Dermatol.
Bullous systemic lupus erythematosus: Systemic lupus erythematosus in a multiethnic US cohort. Se continuar a navegar, consideramos que aceita o seu uso. Bullous systemic lupus erythematosus with milia and calcinosis.
Lupus ampolloso: un verdadero reto diagnóstico y terapéutico | Biociencias
Concurrent painful oral ulcers were reported; though, other mucosae were uninvolved. J Invest Dermatol, 81pp. The course of the disease is benign with remission reported in most of the cases within a year, including ours. Systemic lupus erythematosus occurring in a patient with epidermolysis bullosa acquisita. Vibeke Strand et al.
Footnotes Source of Support: There was only partial improvement with new lesions developing even after 4 weeks; wherein, she was started on dapsone. Hermann Pinkus memorial Lecture Extensive serological workup revealed antinuclear antibody positivity of 1: Bullous dermatosis and systemic lupus erythematosus in a year-old boy. Estelle Hau, MD et al. J Cutan Pathol, bkllosopp. J Invest Dermatol ; J Invest Dermatol, 84pp.
Bullous Systemic Lupus Erythematosus
Journal of Immunology Bulkoso. The case is presented for its typical and distinctive features which should prompt an astute physician to suspect and investigate underlying systemic manifestations of SLE. Evidence supporting a role for immune complex-mediated inflammation in the pathogenesis of bullous lesions of systemic lupus erythematosus.
Lupud a normal glucose 6-Phosphate dehydrogenase G6PD activity, we planned to start her on dapsone; however, her low hemoglobin prevented this.
Autoantibodies to type VII collagen have heterogeneous subclass and light chain compositions and their complement-activating capacities do not correlate with the inflammatory clinical phenotype. Bullous skin lesions in systemic lupus erythematosus.
Lupus ampolloso: un verdadero reto diagnóstico y terapéutico
Lupus, 6pp. Continuing navigation will be considered as acceptance of this use.
Lupus erythematosus in the s: Am J Clin Dermatol ; BMJ – Rheumatic and musculoskeletal diseases. Subepidermal blister formation in the course of severe systemic lupus erythematosus SLE can occur due to extensive interface inflammation and basal cell vacuolation, presenting as polycyclic erosions with advancing blistering border predominantly on sun-exposed areas. Vesiculobullous systemic lupus erythematosus. Vesiculobullous systemic lupus erythematosus.
Sem Cut Med Surg, 17pp. EBA is histopathologically and immunopathologically identical, as it is also mediated by antibodies to type VII collagen; however, a dramatic response to dapsone, as in our case, helps differentiate the two as EBA is notoriously resistant to treatment.
Over the next 6 months, steroids were completely withdrawn, and dapsone and hydroxychloroquine continued for further 1 year. Autoantibody mediated bullodo regulate clinical-pathological phenotypes of acquired epidermolysisbullosa and bullous SLE. Diagnostic immunohistochemistry of the skin, pp.
Bullous systemic lupus erythematosus with cutaneous mucinosis and leukocytoclastic vasculitis.
Bullous Systemic Lupus Erythematosus
Type I fulfilling all six criteria, while Type II undetermined antigen or dermal antigen other than type VII collagen satisfies criteria only. Diagnostic methods in autoimmune subepidermal bullous diseases.
Epidermolysis bullosa acquisita with features of bullous lupus erythematosus.
She responded quite favorably with no new lesions and satisfactory healing of pre-existing ones [ Figure 3 ].